I would have Jericho vs Dolph Ziggler for the WHC. You can either:
A. Have Ziggler cash in soon on Del Rio and have Y2J win a No.1 Contender's Match
B. Have Jericho win at EC and have Ziggler cash in then
C. Have Jericho win at EC and have Ziggler say he will cash in at WM29
D. Have Jericho win at EC, have Ziggler save his contract and win a No.1 Contender's Match thus he could become the first person to have a World Title and still have the MITB briefcase, or he could cash in right after Jericho beats him at Wrestlemania giving him more heel heat.
If not this, then Jericho vs Wade Barret for the IC Title would be interesting considering it would be Teacher vs. Student.